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SHORT-TERM EFFICACY OF A COMBINATION OF GLUCOSAMINE AND CHONDROITIN SULFATE COMPARED TO A COMBINATION OF GLUCOSAMINE, CHONDROITIN SULFATE AND CALCIUM FRUCTOBORATE (CFB) ON IMPROVEMENT OF KNEE DISCOMFORT CONDITIONS IN HEALTHY SUBJECTS. A COMPARATIVE, DOUBLE-BLIND, PLACEBO CONTROLLED ACUTE CLINICAL STUDY
T. Reyes-Izquierdo, M.J. Phelan, R. Keller, C. Shu, R. Argumedo, Z. Pietrzkowski
J Aging Res Clin Practice 2014;3(4):223-228Show summaryHide summary
Purpose: To compare and evaluate the effects of treatment with a blend of glucosamine and chondroitin sulfate, or a blend of glucosamine, chondroitin sulfate and calcium fructoborate as compared to a placebo, on joint discomfort. Methods: Individuals with self-reported knee discomfort were randomized and blinded to treatment with a combo containing glucosamine and chondroitin sulfate or glucosamine, chondroitin sulfate and calcium fructoborate. Both groups were compared to placebo. Symptoms of discomfort and joint function were assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the McGill Pain Questionnaire (MPQ) before treatment and after 7 and 14 days of treatment. Results: Ninety individuals were selected for this study and were randomly assigned in groups of 30 containing 15 male and 15 female participants to each of three treatment conditions. Treatment with glucosamine combined with chondroitin sulfate and CFB resulted in a statistically significant 24% reduction of mean WOMAC score and a 25% reduction of mean McGill index at day 14 over baseline (p-value = 0.0006 and p-value < 0.0001, respectively). Treatment with placebo or with glucosamine and chondroitin material did not result in significant improvement of the conditions. Conclusions: Results showed that short-term treatment with glucosamine and chondroitin could be efficacious only if used in combination with CFB.
T. Reyes-Izquierdo ; M.J. Phelan ; R. Keller ; C. Shu ; R. Argumedo ; Z. Pietrzkowski (2014): SHORT-TERM EFFICACY OF A COMBINATION OF GLUCOSAMINE AND CHONDROITIN SULFATE COMPARED TO A COMBINATION OF GLUCOSAMINE, CHONDROITIN SULFATE AND CALCIUM FRUCTOBORATE (CFB) ON IMPROVEMENT OF KNEE DISCOMFORT CONDITIONS IN HEALTHY SUBJECTS. A COMPARATIVE, DOUBLE-BLIND, PLACEBO CONTROLLED ACUTE CLINICAL STUDY. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2014.39
AN OVERVIEW ON ASSESSMENT TESTS FOR ALZHEIMER’S DISEASE IN MEXICO. THE NATIONAL DEMENTIA SURVEY: A STUDY FROM THE MEXICAN GROUP OF SPECIALISTS IN DEMENTIAS
S.P. Ramírez Díaz, G.Albert Meza, R.E. Albrecht Junghanns, I.C. Zúñiga Gil, M.A. Bedia Reyes, L.A. Barba Valadez, E. Almanza Huante
J Aging Res Clin Practice 2015;4(1):44-49Show summaryHide summary
Objective: To know the current status of the clinical assessment tests used to evaluate Alzheimer’s disease (AD) and memory-related dementias in specific regions throughout Mexico. Design, patients and settings: Patients with objective memory impairment were subjected to a clinical survey in medical centers specializing in memory loss. Each patient’s consultation was conducted like a routine clinical practice. Patient’s data were recorded using an anonymous patient survey. The most prominent behavioral problems were recorded. Results: 1350 patients were tested, 65.19% female (n=880). Out of 1350 patients, 76.59% (n=1034) had been previously diagnosed with any kind of dementia. The most common diagnosis concerning cognitive impairment was AD (54.2%, n=560) and Vascular Dementia (VaD, 19.7%, n=204). Minimental State Examination (MMSE) was performed in all patients and the average score was of 18±7. Katz scale for Activities of Daily Living (ADL) was performed in 49.41% (n=667) of patients, Lawton and Brody scale for Instrumental activities of daily living (IADL) in 35.78% (n=483), and Geriatric Depression Scale (GDS-Yesavage) in 32.89% (n=444). The most prominent behavioral symptom was apathy (12.15%, n=164).The most frequent concomitant diseases were: high blood pressure in 52.3%, diabetes in 27.0% and Dyslipidemia in 23.4%. Conclusions: Through the assessment of clinical surveys throughout Mexico, it was found that the most common form of dementia is AD and it is followed by VaD. Commonly, the Katz, Lawton and Brody, and the GDS-Yesavage scales are clinical assessment tests that are the most commonly used. There are many differences in the use of tests to evaluate patients with dementia across Mexico. For the first time, we were able to identify tendencies in the assessment of dementias by Mexican physicians.
S.P. Ramírez Díaz ; G.Albert Meza ; R.E. Albrecht Junghanns ; I.C. Zúñiga Gil ; M.A. Bedia Reyes ; L.A. Barba Valadez ; E. Almanza Huante ; Mexican Group of Specialists in Dementias (2015): AN OVERVIEW ON ASSESSMENT TESTS FOR ALZHEIMER’S DISEASE IN MEXICO. THE NATIONAL DEMENTIA SURVEY: A STUDY FROM THE MEXICAN GROUP OF SPECIALISTS IN DEMENTIAS. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2015.49
ALZHEIMER’S COGNITIVE IMPAIRMENT CAN BE CURED BY DECREASING BLOOD HOMOCYSTEIC ACID
T. Hasegawa, T. Uchida, A. Chanoki
J Aging Res Clin Practice 2015;4(2):124-128Show summaryHide summary
Recent big two clinical trials of amyloid beta treatment for Alzheimer’s disease are all failed to recover the cognitive impairment, it has forced us to reconsider the central hypothesis of amyloid pathogen for Alzheimer’s disease. We recently published that human Alzheimer’s patients showed the strong relationship between Mini Mental State Examination (MMSE) scores and blood homocysteic acid (HA) level. However this relationship did not show the pathogenic action of HA. So we investigated the pathogenic effect of blood HA on MMSE score, that is, how does blood HA level change affect MMSE score? 6 AD patients (all female: age 77, 82, 86,87, 91, 91) were given green tea powder 1g at every meal for 2 months. Their blood HA level and MMSE score were measured before and after taking green tea powder. The relationship between blood HA level change and MMSE score change was investigated. The strong statistically significant negative relationship between blood HA level change and MMSE score change: r=-0.96, p=0.00018, n=6. From our observation, it shows that blood HA level change induced MMSE score change, that is, Alzheimer’s cognitive ability was controlled by blood HA level. Now we can present that some healthy food, that is named HBF, can recovered 100% Alzheimer’s cognitive impairment by the decreasing the homocysteic acid in a peripheral blood. We made the open-trial of HBF on the Alzheimer’s and lewy bodies dementia’s cognitive recovery. Two male lewy bodies dementia patients, 11 female Alzheimer’s patients were enrolled. All patients were at end stage. They ingested HBF supplement 1.5g at every meals for 1-2 months. Their MMSE scores were measured before and after their HBF ingestion. Their blood homocysteic acid levels were measured by ELISA method before and after their ingestions. Results were extremely amaging. 100% of all patients showed their cognitive recovery. Their blood homocysteic acid decreased their level by HBF. Now we have made a relative large open trial of AD patients. 91 patients were enrolled. Their cognitive recovery were measured by NM scale (New Clinical Scale for Rating of Mental States). All patients who took HBF showed the recovery of their behaviors. From this open-trial of HBF, many facts can be confirmed. (1) Alzheimer’s cognitive impairment can be recovered at even end stage. (2) Alzheimer’s disease is induced by homocysteic acid.
T. Hasegawa ; T. Uchida ; A. Chanoki (2015): Alzheimer’s cognitive impairment can be cured by decreasing blood homocysteic acid. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2015.59
DIETARY PATTERNS, NUTRIENT INTAKES, AND NUTRITIONAL AND PHYSICAL ACTIVITY STATUS OF SAUDI OLDER ADULTS: A NARRATIVE REVIEW
H. M. Alsufiani, T.A. Kumosani, D. Ford, J.C. Mathers
J Aging Res Clin Practice 2015;4(1):2-11Show summaryHide summary
Objective: to review the dietary patterns, nutrient intakes, and nutritional and physical activity status of older adults living in Saudi Arabia, to examine geographical differences in such patterns and to identify research gaps in respect of nutrition and physical activity for this population group. Design: Databases and websites (including Pubmed, Scopus, Proquest, Google Scholar and Arab Center for Nutrition) were searched in English and Arabic languages using the following key words: nutritional status, dietary pattern, food pattern, dietary habits, micronutrient intake and status, macronutrients intake, obesity, malnutrition, iron deficiency anemia, vitamin D, physical activity, exercise, Saudi older adults and Saudi elderly. All relevant and available data for both free-living and institutionalized Saudi older adults (> 50 years old or with mean age > 50 years) published in the last 20 years were included in this review. Results: We found that free-living females consumed fewer meals, and less fruits and vegetables, but their reported energy intake was higher than for males. Low intake of vitamins C and D were common in both genders and in those who lived in western and northern regions while low intake of folate and fiber were common in institutionalized people. Omega-3 fatty acids and fish were more highly consumed by older adults living in the coastal region compared with residents in the internal region. Obesity, overweight, vitamin D deficiency and insufficiency and physical inactivity were prevalent in free living older adults throughout the country while underweight and iron deficiency anemia were prevalent in institutionalized persons. Conclusion: Information on dietary patterns, nutrient intakes, and nutritional and physical activity status of older adults living in Saudi Arabia is fragmentary and interpretation of the findings is hampered by the lack of population-representative sampling frames and the use of heterogeneous data collection tools. More systematic studies are essential to facilitate objective assessment of these important lifestyle-related factors and to inform public health policies.
H. M. Alsufiani ; T.A. Kumosani ; D. Ford ; J.C. Mather (2015): DIETARY PATTERNS, NUTRIENT INTAKES, AND NUTRITIONAL AND PHYSICAL ACTIVITY STATUS OF SAUDI OLDER ADULTS: A NARRATIVE REVIEW. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2015.46
BODY COMPOSITION AND HAND GRIP STRENGTH IN HEALTHY COMMUNITY-DWELLING OLDER ADULTS IN SWEDEN
A. Lindblad, S. Dahlin-Ivanoff, I. Bosaeus, E. Rothenberg
J Aging Res Clin Practice 2015;4(1):154-58Show summaryHide summary
Background: Longevity increases worldwide but there are few studies on body composition and hand grip strength in populations over 80 years. Given high prevalence of chronic disease and functional disability in octogenarians, it may be difficult to distinguish effects of ageing from those imposed by disease. The European Consensus definition of sarcopenia recommends using both low muscle mass and function for diagnosis. Objectives: Examine body composition and hand grip strength in a selected group of community-dwelling older adults with high level of functional independence. In addition, longitudinal changes in handgrip strength were examined using previously collected data. Design: Cross-sectional body composition and hand grip strength with a four year retrospective analysis on previously assessed hand grip strength. Setting: Measurements were conducted by home visits. Participants: 102 community-dwelling 83-96 year-olds, 50 % women. Measurements: Hand grip strength was registered by a dynamometer and body composition analysis using bioimpedance spectroscopy. Results: According to European Consensus definition, only 6/102 had normal muscle mass - no men, although 78 % of men and 40 % of women had normal muscle strength. Since previously collected data four years earlier, men had lost strength (p<0.001), while women had not (p=0.202). Conclusions: Subject characteristics and health status support well-preserved body energy, protein stores and muscle strength. Low muscle mass was much more prevalent than low muscle strength. Results may give an indication of what constitutes a healthy body composition in oldest old and could serve as a starting point for reference values on healthy body composition in octogenarians.
A. Lindblad ; S. Dahlin-Ivanoff ; I. Bosaeus ; E. Rothenberg (2015): BODY COMPOSITION AND HAND GRIP STRENGTH IN HEALTHY COMMUNITY-DWELLING OLDER ADULTS IN SWEDEN. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2015.50