DECREASING LEVELS OF SPORACETIGENIUM CORRELATE WITH IMPROVED DIABETIC PARAMETERS IN HEALTHY ADULTS CONSUMING MSPREBIOTIC® DIGESTION RESISTANT STARCH
J.R. Bush, M.J. Alfa
J Aging Res Clin Practice 2018;7:176-180
Objective: To determine whether changes in specific Firmicutes genera are correlated with changes in blood glucose and/or insulin levels in participants consuming MSPrebiotic® digestion resistant starch (DRS). Design: Double-blinded, randomized placebo-controlled trial (September 2013 to May 2015). Participants: Mid-aged (MID) adults aged 30-50 years (42 enrolled, 40 analyzed) and elderly (ELD) adults 70 years or older (42 enrolled, 35 analyzed), including long-term care facility (ELD) and community dwellers (MID and ELD) in Winnipeg, Canada. Intervention: Participants consumed 30 g placebo (digestible starch) daily for 2 weeks and were then randomized to receive 30 g per day placebo or 30 g per day DRS for 3 months. Measurements: Correlations between abundance of all Firmicutes genera detected in the gut microbiome and blood glucose and insulin levels were calculated. Significance was determined using the Benjamini-Hochberg procedure. Results: We report significant correlations between changes in blood glucose and change in Butyricicoccus (r = - 0.59212, p = 0.007578) and change in Sporacetigenium (r = 0.637197; p = 0.003349) in the ELD group consuming DRS, and significant correlations between the changes in blood glucose and change in Roseburia (r = 0.55731, p = 0.013178), change in Sporacetigenium (r = 0.572948, p = 0.010351), and change in Anaerostipes (r = - 0.59026; p = 0.007836) in the MID group consuming DRS. Sporacetigenium abundance at baseline is significantly correlated with insulin levels in the general population (r = 0.337136901; p = 0.003102). Conclusion: Sporacetigenium abundance in the gut microbiome is correlated with diabetic parameters in both MID and ELD groups and may be a microbiome marker that parallels the development of diabetes.
J.R. Bush ; M.J. Alfa (2018): Decreasing levels of Sporacetigenium correlate with improved diabetic parameters in healthy adults consuming MSPrebiotic® digestion resistant starch. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2018.28