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03/2016 journal articles

STIMULATORY EFFECT OF ACUTE SINGLE DOSE OF DRIED WHOLE COFFEE CHERRY POWDER ON NRF2 ACTIVITY IN FRESHLY ISOLATED BLOOD CELLS. A SINGLE-BLIND, PLACEBO CONTROLLED CROSS-OVER PILOT CLINICAL STUDY

T. Reyes-Izquierdo, B. Nemzer, R. Argumedo, M. Cervantes, Z. Pietrzkowski

J Aging Res Clin Practice 2016;5(3):120-127

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Abstract: Background: NF-E2-related factor 2 (Nrf2) is a transcription factor that participates in the regulation of antioxidant expression during increased oxidant stress. Several phytochemicals and food products have shown to trigger Nrf2 activity. In this pilot placebo-controlled study the effects of a single dose of dried whole coffee cherry powder (“WCCP”) on Nrf2 levels were tested. Objectives: To characterize a blend of WCCP and evaluate the potential effects on mTOR and Nrf2 in healthy subjects. Design: In this cross over study, subjects were given placebo or a single dose of 1000mg WCCP on day 1 and 2. Blood was collected for four time points. Participants served as their own controls. Setting: After supplementation, blood samples were processed for mTOR and Nrf2 analysis. Blood ATP, glucose and lactate were also measured. Participants: Ten healthy subjects, ages ranging from 22 to 35 years and BMI ranging from 24.1 to 30 kg/m² were selected to participate. Results: One 1000 mg dose of WCCP resulted in an average 44% increase of NRf2 levels 180 minutes after ingestion (p=0.03 ). Phosphorylated mTOR (Ser 2448) was reduced at 180 minutes after supplement; when compared to placebo. Correlation (“Corr”) analyses revealed that increases in Nrf2 appear to be associated with mTOR reduction. Blood glucose and extracellular ATP levels were not changed. Conclusions: WCCP increased Nrf2 3 hours after ingestion. Additional testing is required to verify the potency of WCCP on Nrf2, as well as any potential correlation between mTOR (S2448) reduction and increased levels of Nrf2 after supplementation.

CITATION:
T. Reyes-Izquierdo ; B. Nemzer ; R. Argumedo ; M. Cervantes ; Z. Pietrzkowski (2016): Stimulatory effect of acute single dose of dried whole coffee cherry powder on Nrf2 activity in freshly isolated blood cells. A single-blind, placebo controlled cross-over pilot clinical study. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.109

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CAN CONTINUOUS, INTER-GENERATIONAL COOPERATION POSITIVELY IMPACT? FINAL RESULT

R. Rokkaku, A. Homma, S. Kobayashi, Y. Seki

J Aging Res Clin Practice 2016;5(3):128-131

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An aim of the present study is to examine the impact of inter-generational cooperation on the quality of life of elderly Alzheimer’s sufferers. The study is a continuing, two-year intervention report. The subject consist of an intervention and a control groups of six and five sufferers, respectively, who were diagnosed with Alzheimer’s disease. Both groups attend day care services. The intervention group participates in the inter-generational program with children, while the control group does not. In the results, the score of Quality of Life – Alzheimer’s disease (QOL-AD ) of the subjects has been significantly higher in the intervention group comparing with that of the control group. been significantly higher in the intervention group comparing with that of the control group. Also the Philadelphia Geriatric Center Affect Rating Scale(PGC-ARS), have been significantly higher in the intervention group those in the control group., The magnitude of the change was not so remarkable as to influence QOL-AD at home. The present intergenerational cooperation may improve the quality of life of moderate to severe Alzheimer’s sufferers.

CITATION:
R. Rokkaku1 ; A. Homma ; S. Kobayashi ; Y. Seki (2016): Can continuous, inter-generational cooperation positively impact. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.102

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METABOLIC SYNDROME PREVALENCE IS NOT ASSOCIATED WITH DIET QUALITY IN THE CHILEAN ELDERLY POPULATION: A CROSS SECTIONAL ANALYSIS FROM THE NATIONAL HEALTH SURVEY 2009-2010

C. Dussaillant, G. Echeverría, L. Villarroel, C.B. Yu, A. Rigotti, P.P. Marín

J Aging Res Clin Practice 2016;5(3):132-138

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Objectives: To analyze the relationship between the prevalence of metabolic syndrome, food intake, and diet quality in elderly (≥65 years old) Chilean population. Design: Cross sectional analysis based on the last national health survey performed in the years 2009 and 2010 (ChNHS 2009-2010). Setting: Non-institutionalized individuals of 65 years or older were selected and visited at home. Participants: A subsample of 505 elderly adults from the ChNHS 2009-2010 who answered a food questionnaire and had appropriate information to diagnose metabolic syndrome following the ATPIII-NCEP guidelines. Measurements: Fasting blood samples were obtained in order to measure blood lipids and fasting blood glucose. Blood pressure, waist circumference, and body mass index (BMI) were also measured. A 5-item food frequency questionnaire was applied to all the participants of NHS 2009-2010. Results: The overall prevalence of metabolic syndrome in the Chilean adult population was 37.7%, increasing in frequency with advancing age. Among the elderly (≥65 years old), metabolic syndrome was found in 57.2% of the sample. Elevated blood pressure and increased waist circumference were the most prevalent metabolic syndrome components among this group (88% and 80%, respectively). Low intake of fruits, vegetables, whole cereals, fish, and dairy was seen among the elderly, and no association was found between food intake nor diet quality and metabolic syndrome prevalence. Conclusion: Metabolic syndrome is highly prevalent among the Chilean elderly population and its prevalence is not associated with food intake or diet quality in this age group.

CITATION:
C. Dussaillant ; G. Echeverría ; L. Villarroel ; C.B. Yu ; A. Rigotti ; P.P. Marín (2016): METABOLIC SYNDROME PREVALENCE IS NOT ASSOCIATED WITH DIET QUALITY IN THE CHILEAN ELDERLY POPULATION: A CROSS SECTIONAL ANALYSIS FROM THE NATIONAL HEALTH SURVEY 2009-2010. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.104

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EVALUATING THE POTENTIAL BENEFITS OF CUCUMBERS FOR IMPROVED HEALTH AND SKIN CARE

H. Murad, M.A. Nyc

J Aging Res Clin Practice 2016;5(3):139-141

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Epidemiological and nutritional studies indicate that cucumbers, a fruit in the cucurbitaceae family, have numerous benefits internally, externally and even emotionally. As a food, cucumbers offer superior hydration, as they are about 95% water. They have been used for decades for their anti-inflammatory benefits on skin, soothing properties for digestion, and other therapeutic uses. The following contribution offers an overview of cucumbers, specifically, their use to augment cellular water and address common conditions (i.e.: skin discoloration and aging, cardiovascular and cancerous diseases, bone health, inflammation, and connective tissue disorders).

CITATION:
H. Murad ; M.A. Nyc (2016): Evaluating the potential benefits of cucumbers for improved health and skin care. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.108

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DEPRESSIVE SYMPTOMS AND LEVEL OF 25-HYDROXYVITAMIN D IN FREE-LIVING OLDEST OLD

M.T. da Rocha Lima, O. Custódio, P. Ferreira do Prado Moreira, L.M. Quirino Araujo, C. de Mello Almada Filho, M. Seabra Cendoroglo

J Aging Res Clin Practice 2016;5(3):142-146

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Background: Nowadays, the relation between hypovitaminosis D and depression has been reported and it is estimated that 1 billion people worldwide have vitamin D deficiency or insufficiency. However, the oldest old people are not included or are under-represented in most of the studies. Objective: To examine the association between depressive symptoms and 25-hydroxyvitamin D level (25(OH)Vit D) in elderly aged 80 and over who are physically more active and independent. Design: Cross-sectional study. Setting and Participants: Data collected from 182 oldest old people, aged 80 and over in the Geriatric Division from Federal University of São Paulo. Measurements: The functionality was evaluated by the Instrumental activities of their daily living (IADL). The approach of the depressive symptoms was done by the Geriatric Depression Scale (GDS) in its reduced 15 item version. 25-hydroxyvitamin D (25(OH)Vit D) analyses was done in serum sample refrigerated and protected from solar exposition. We considered deficiency serum level of 25(OH)Vit D <10ng/mL, insufficiency between 10 and 30ng/mL and sufficiency >30ng/mL. Results: According to blood level of 25(OH)Vit D we found difference between GDS score comparing the groups: “deficiency” (U=144,50; z=-3,126; p=0,002) and “insufficiency” groups (U=975,50; z=-2,793; p=0.005) are different than “sufficiency” group. Conclusion: In free-living independent oldest old people the goal of 25(OH)Vit D levels can be higher to avoid depressive symptoms, levels under 30ng/mL can be inadequate. Considering that the costs are low and side effects are not common, 25(OH)Vit D supplementation can be an important public health action.

CITATION:
M.T. da Rocha Lima ; O. Custódio ; P. Ferreira do Prado Moreira ; L.M. Quirino Araujo ; C. de Mello Almada Filho ; M. Seabra Cendoroglo (2016): DEPRESSIVE SYMPTOMS AND LEVEL OF 25-HYDROXYVITAMIN D IN FREE-LIVING OLDEST OLD. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.101

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UPPER EXTREMITY MUSCLE VOLUME AND FUNCTION AS INDICATORS OF PRE-FRAILTY IN OLDER ADULT PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

E. Miyamoto, M. Kaneko3, , E. Miyamoto, M. Kaneko, S. Ichimaru, Y. Hokotachi, T. Amagai

J Aging Res Clin Practice 2016;5(3):147-154

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Background: In a survey of 2004 conducted by World Health Organization, chronic obstructive pulmonary disease (COPD) is proved third leading cause of death worldwide and develops frailty. However, the differences between pre-frailty and non-frailty or frailty are not well studied. Objective: To examine the working hypothesis that there is differences in phenotypes between pre-frailty and non-frailty or frailty in patients with COPD. Design and setting: This study is a cross-sectional study. Participants: Patients with consecutive COPD male patients, whose age is 50 year-old or older, visited COPD outpatient clinic at single institute, between 2011, March and August, were eligible. Measurements: The data categorized into seven domains according to Fried’s phenotypic criteria were collected in all subjects divided into three groups: non-, pre-, and frailty. All data was compared between two of three groups. Results: Pre-frail COPD patients showed declines in upper extremities’ muscle volume and functions assessed by arm muscle area and hand-grip strength (P<0.05) compared with data in non-frailty group. This was different from results of comparison data between pre- and frailty group where lower extremities’ muscle data showed statistically different (p<0.05). Conclusion: Our observation could be interpreted that declines in upper extremities’ muscle volume and function might precede in comparison pre-frailty with non-frailty COPD patients. This might be an early predictor to progressing the severity of COPD in pre-frail COPD patients and might be potential factor to prevent deterioration of frailty and COPD severity.

CITATION:
E. Miyamoto ; M. Kaneko ; S. Ichimaru ; Y. Hokotachi ; T. Amagai (2016): Upper extremity muscle VOLUME AND function as indicatorS of pre-frailty in older adult patients with chronic obstructive pulmonary disease (COPD). The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.103

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AIMCO CRITERIA (ADEQUACY OF INVASIVE MANAGEMENT OF ACUTE CORONARY SYNDROME IN OLDER PATIENTS): A PROPOSAL TO ADAPT DECISION MAKING

B. Alvarez-Fernandez, I. Ribera Cabeo, M.R. Bernal-Lopez, M. de Mora Martin, C. Urbano Carrillo, G. Quesada Garcia, J.A. Arboleda, R. Gomez Huelgas

J Aging Res Clin Practice 2016;5(3):155-157

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CITATION:
B. Alvarez-Fernandez ; I. Ribera Cabeo ; M.R. Bernal-Lopez ; M. de Mora Martin ; C. Urbano Carrillo ; G. Quesada Garcia ; J.A. Arboleda ; R. Gomez Huelgas (2016): AIMCO Criteria (Adequacy of Invasive Management of Acute Coronary Syndrome in Older Patients): A proposal to adapt decision making. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.105

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AN EVALUATION OF NUTRITIONAL INDEXES FOR TO PREDICTION THE HOSPITALIZATION DURATION IN ELDERLY CHRONIC KIDNEY DISEASE PATIENTS

B. Buyukaydin, A.T. Isik, P. Soysal, M. Alay, R. Kazancioglu

J Aging Res Clin Practice 2016;5(3):158-161

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Objective: Chronic kidney disease and malnutrition are serious and frequently encountered co-morbidities among older patients. We evaluated nutritional status of older pre-dialysis patients and the effect of malnutrition on length of stay (LOS) in hospital. Materials and Methods: 65 years and over 33 hospitalized pre-dialysis patients with glomerular filtration rate between 10-30ml/min/1.73m2 were included. There is no control group. For all patients, biochemical analysis was performed. The malnutrition risk was evaluated with Mini Nutritional Assessment Short-Form (MNA-SF) and Geriatric Nutritional Risk Index (GNRI) and LOS in hospital was recorded. Results: Mean GNRI was 98.4±12.9 and the mean MNA-SF was 8±3.15. For all patients, mean LOS was 10.58±9 days. According to MNA-SF, malnourished patients’ LOS was longer and a difference was observed between MNA-SF and GNRI in terms of LOS prediction (p=0.005, p=0.230). Conclusion: For older pre-dialysis patients, MNA-SF is probably a more sensitive index in terms of LOS in hospital prediction.

CITATION:
B. Buyukaydin ; A.T. Isik ; P. Soysal ; M. Alay ; R. Kazancioglu (2016): AN EVALUATION OF NUTRITIONAL INDEXES FOR TO PREDICTION THE HOSPITALIZATION DURATION IN ELDERLY CHRONIC KIDNEY DISEASE PATIENTS. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.106

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SARCOPENIA PREVALENCE AND ASSOCIATED FACTORS IN ELDERLY PEOPLE ASSISTED BY PRIMARY HEALTH CARE, SÃO PAULO, BRAZIL: A CROSS-SECTIONAL STUDY SARCOPENIA PREVALENCE IN ELDERLY

L. Campos Aparecido Martins, P.J. Fortes Villas Bôas, K.C. Portero McLellan

J Aging Res Clin Practice 2016;5(3):162-166

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Background: Sarcopenia is prevalent in the elderly population and has been postulated as the main factor for the decline in strength with age, representing a health deficient state with a personal high cost. Objective: To identify the prevalence of sarcopenia and its association with anthropometric and socioeconomic factors in elderly patients assisted by primary health care. Design and Methods: Cross-sectional study conducted with 136 individuals aged 60 years and older. Socioeconomic and demographic status, and anthropometric profile were assessed for all individuals. For the diagnosis of sarcopenia it was considered muscle wasting associated with loss of muscle strength. Logistic regression model was performed to identify the risk factors for sarcopenia considering a 5% significance level for the corresponding p-value. Results: The prevalence of sarcopenia in the studied population was 37.5%, however being higher among men (66.6%). Of those individuals with sarcopenia, 50% of men and 29% of women were overweight, 35% of men and 64% of women had abnormal waist to hip ratio. Retirement (OR: 2.165; CI: 1.037 to 4.250) and smoking (OR: 9.435; CI: 1.228 to 72.499) represented risk factors for sarcopenia. Conclusion: The study population had a high prevalence of sarcopenia, along with a high prevalence of abdominal obesity, which may be an important causal factor for insulin resistance and type 2 diabetes susceptibility. Sarcopenia was associated with behavioral (smoking) and demographic (retirement) variables.

CITATION:
L. Campos Aparecido Martins ; P.J. Fortes Villas Bôas ; K.C. Portero McLellan (2016): Sarcopenia prevalence and associated factors in elderly people assisted by Primary Health Care, São Paulo, Brazil: A cross-sectional study Sarcopenia prevalence in elderly. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.107

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MONITORING THE NUTRITIONAL STATUS OF PATIENTS WITH PRESSURE ULCERS USING THE CONTROLLING NUTRITIONAL STATUS METHOD

H. Kishimoto

J Aging Res Clin Practice 2016;5(3):167-169

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Objectives: To evaluate methods for monitoring the nutritional status of patients with pressure ulcers (PU). Design: A retrospective case series study. Setting and Participants: Twenty-nine patients (mean age, 80.6 years; 10 men) with PU admitted to the acute care ward of Namegata District General Hospital, Japan, were recruited. Measurements: The nutritional status of the patients was evaluated using the controlling nutritional status (CONUT) method. The wound assessment tool DESIGN-R was used to evaluate the wound state of PU. The rate of improvement in CONUT score (CR) was calculated for each patient from the CONUT values at the beginning and end of the observation period divided by the number of days. In addition, the rates of improvement of the serum albumin level (AR) and DESIGN-R level (DR) were also calculated. Results: There was a moderately strong correlation between CR and DR that was significant (r = 0.60, p < 0.01); however, the correlation between AR and DR was weaker and not significant (r = 0.36, p = 0.056). Conclusion: Improvement in nutritional status evaluated by CONUT correlated with the improvement in ulcer severity evaluated by DESIGN-R in patients with PU. The CONUT method is suitable for nutritional status monitoring of the patient with PU in a hospital setting.

CITATION:
H. Kishimoto (2016): Monitoring the nutritional status of patients with pressure ulcers using the controlling nutritional status method. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.110

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